diff --git a/dtool/src/interrogate/interfaceMakerPythonNative.cxx b/dtool/src/interrogate/interfaceMakerPythonNative.cxx
index bf0ff5d333..2856c95fba 100644
--- a/dtool/src/interrogate/interfaceMakerPythonNative.cxx
+++ b/dtool/src/interrogate/interfaceMakerPythonNative.cxx
@@ -2570,6 +2570,8 @@ write_module_class(ostream &out, Object *obj) {
     out << "    return nullptr;\n";
     out << "  }\n\n";
 
+    bool have_eq = false;
+    bool have_ne = false;
     for (Function *func : obj->_methods) {
       std::set<FunctionRemap*> remaps;
       if (!func) {
@@ -2590,8 +2592,10 @@ write_module_class(ostream &out, Object *obj) {
         op_type = "Py_LE";
       } else if (fname == "operator ==") {
         op_type = "Py_EQ";
+        have_eq = true;
       } else if (fname == "operator !=") {
         op_type = "Py_NE";
+        have_ne = true;
       } else if (fname == "operator >") {
         op_type = "Py_GT";
       } else if (fname == "operator >=") {
@@ -2616,6 +2620,43 @@ write_module_class(ostream &out, Object *obj) {
     }
 
     if (has_local_richcompare) {
+      if (have_eq && !have_ne) {
+        // Generate a not-equal function from the equal function.
+        for (Function *func : obj->_methods) {
+          std::set<FunctionRemap*> remaps;
+          if (!func) {
+            continue;
+          }
+          const string &fname = func->_ifunc.get_name();
+          if (fname != "operator ==") {
+            continue;
+          }
+          for (FunctionRemap *remap : func->_remaps) {
+            if (is_remap_legal(remap) && remap->_has_this && (remap->_args_type == AT_single_arg)) {
+              remaps.insert(remap);
+            }
+          }
+          out << "  case Py_NE: // from Py_EQ\n";
+          out << "    {\n";
+
+          string expected_params;
+          write_function_forset(out, remaps, 1, 1, expected_params, 6, true, false,
+                                AT_single_arg, RF_pyobject | RF_invert_bool | RF_err_null, false);
+
+          out << "      break;\n";
+          out << "    }\n";
+        }
+      }
+      else if (!have_eq && !slots.count("tp_compare")) {
+        // Generate an equals function.
+        out << "  case Py_EQ:\n";
+        out << "    return PyBool_FromLong(DtoolInstance_Check(arg) && DtoolInstance_VOID_PTR(self) == DtoolInstance_VOID_PTR(arg));\n";
+        if (!have_ne) {
+          out << "  case Py_NE:\n";
+          out << "    return PyBool_FromLong(!DtoolInstance_Check(arg) || DtoolInstance_VOID_PTR(self) != DtoolInstance_VOID_PTR(arg));\n";
+        }
+      }
+
       // End of switch block
       out << "  }\n\n";
       out << "  if (_PyErr_OCCURRED()) {\n";
@@ -6048,8 +6089,13 @@ write_function_instance(ostream &out, FunctionRemap *remap,
       return_flags &= ~RF_pyobject;
 
     } else if (return_null && TypeManager::is_bool(remap->_return_type->get_new_type())) {
-      indent(out, indent_level)
-        << "return Dtool_Return_Bool(" << return_expr << ");\n";
+      if (return_flags & RF_invert_bool) {
+        indent(out, indent_level)
+          << "return Dtool_Return_Bool(!(" << return_expr << "));\n";
+      } else {
+        indent(out, indent_level)
+          << "return Dtool_Return_Bool(" << return_expr << ");\n";
+      }
       return_flags &= ~RF_pyobject;
 
     } else if (return_null && TypeManager::is_pointer_to_PyObject(remap->_return_type->get_new_type())) {
@@ -6415,7 +6461,12 @@ pack_return_value(ostream &out, int indent_level, FunctionRemap *remap,
       indent(out, indent_level)
         << "return PyString_FromStringAndSize((char *)return_value.data(), (Py_ssize_t)return_value.size());\n";
       out << "#endif\n";
-    } else {
+    }
+    else if (return_flags & RF_invert_bool) {
+      indent(out, indent_level)
+        << "return Dtool_WrapValue(!(" << return_expr << "));\n";
+    }
+    else {
       indent(out, indent_level)
         << "return Dtool_WrapValue(" << return_expr << ");\n";
     }
diff --git a/dtool/src/interrogate/interfaceMakerPythonNative.h b/dtool/src/interrogate/interfaceMakerPythonNative.h
index c667ab22fa..b387cf0001 100644
--- a/dtool/src/interrogate/interfaceMakerPythonNative.h
+++ b/dtool/src/interrogate/interfaceMakerPythonNative.h
@@ -115,6 +115,9 @@ private:
 
     // This raises a KeyError on falsey (or -1) return value.
     RF_raise_keyerror = 0x4000,
+
+    // Invert boolean return value.
+    RF_invert_bool = 0x8000,
   };
 
   class SlottedFunctionDef {