diff --git a/makepanda/makewheel.py b/makepanda/makewheel.py
index e69f8a3db8..0aa37e2b8e 100644
--- a/makepanda/makewheel.py
+++ b/makepanda/makewheel.py
@@ -407,6 +407,7 @@ class WheelFile(object):
                     deps_path = '@executable_path/../Frameworks'
                 else:
                     deps_path = '@loader_path'
+                remove_signature = False
                 loader_path = [os.path.dirname(source_path)]
                 for dep in deps:
                     if dep.endswith('/Python'):
@@ -439,6 +440,11 @@ class WheelFile(object):
                         continue
 
                     subprocess.call(["install_name_tool", "-change", dep, new_dep, temp.name])
+                    remove_signature = True
+
+                # Remove the codesign signature if we modified the library.
+                if remove_signature:
+                    subprocess.call(["codesign", "--remove-signature", temp.name])
             else:
                 # On other unixes, we just add dependencies normally.
                 for dep in deps: