diff --git a/include/mbedtls/pk.h b/include/mbedtls/pk.h
index a226e7173..ec8355136 100644
--- a/include/mbedtls/pk.h
+++ b/include/mbedtls/pk.h
@@ -402,6 +402,11 @@ int mbedtls_pk_can_do(const mbedtls_pk_context *ctx, mbedtls_pk_type_t type);
  *                  Use \c mbedtls_pk_verify_ext( MBEDTLS_PK_RSASSA_PSS, ... )
  *                  to verify RSASSA_PSS signatures.
  *
+ * \note            If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                  subsystem must have been initialized by calling
+ *                  psa_crypto_init() before calling this function,
+ *                  if the key might be an ECC (ECDSA) key.
+ *
  * \note            If hash_len is 0, then the length associated with md_alg
  *                  is used instead, or an error returned if it is invalid.
  *
diff --git a/include/mbedtls/ssl.h b/include/mbedtls/ssl.h
index 7836ecec6..26e4ec400 100644
--- a/include/mbedtls/ssl.h
+++ b/include/mbedtls/ssl.h
@@ -1544,6 +1544,10 @@ void mbedtls_ssl_init(mbedtls_ssl_context *ssl);
  *                 Calling mbedtls_ssl_setup again is not supported, even
  *                 if no session is active.
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param ssl      SSL context
  * \param conf     SSL configuration to use
  *
@@ -3980,6 +3984,10 @@ int mbedtls_ssl_get_session(const mbedtls_ssl_context *ssl, mbedtls_ssl_session
  *                 in which case the datagram of the underlying transport that is
  *                 currently being processed might or might not contain further
  *                 DTLS records.
+ *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
  */
 int mbedtls_ssl_handshake(mbedtls_ssl_context *ssl);
 
diff --git a/include/mbedtls/x509_crl.h b/include/mbedtls/x509_crl.h
index 895eca0d6..140502140 100644
--- a/include/mbedtls/x509_crl.h
+++ b/include/mbedtls/x509_crl.h
@@ -95,6 +95,10 @@ mbedtls_x509_crl;
 /**
  * \brief          Parse a DER-encoded CRL and append it to the chained list
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param chain    points to the start of the chain
  * \param buf      buffer holding the CRL data in DER format
  * \param buflen   size of the buffer
@@ -109,6 +113,10 @@ int mbedtls_x509_crl_parse_der(mbedtls_x509_crl *chain,
  *
  * \note           Multiple CRLs are accepted only if using PEM format
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param chain    points to the start of the chain
  * \param buf      buffer holding the CRL data in PEM or DER format
  * \param buflen   size of the buffer
@@ -124,6 +132,10 @@ int mbedtls_x509_crl_parse(mbedtls_x509_crl *chain, const unsigned char *buf, si
  *
  * \note           Multiple CRLs are accepted only if using PEM format
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param chain    points to the start of the chain
  * \param path     filename to read the CRLs from (in PEM or DER encoding)
  *
diff --git a/include/mbedtls/x509_crt.h b/include/mbedtls/x509_crt.h
index 235e00c06..466611f79 100644
--- a/include/mbedtls/x509_crt.h
+++ b/include/mbedtls/x509_crt.h
@@ -283,6 +283,10 @@ extern const mbedtls_x509_crt_profile mbedtls_x509_crt_profile_suiteb;
  * \brief          Parse a single DER formatted certificate and add it
  *                 to the end of the provided chained list.
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param chain    The pointer to the start of the CRT chain to attach to.
  *                 When parsing the first CRT in a chain, this should point
  *                 to an instance of ::mbedtls_x509_crt initialized through
@@ -344,6 +348,10 @@ typedef int (*mbedtls_x509_crt_ext_cb_t)(void *p_ctx,
  * \brief            Parse a single DER formatted certificate and add it
  *                   to the end of the provided chained list.
  *
+ * \note             If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                   subsystem must have been initialized by calling
+ *                   psa_crypto_init() before calling this function.
+ *
  * \param chain      The pointer to the start of the CRT chain to attach to.
  *                   When parsing the first CRT in a chain, this should point
  *                   to an instance of ::mbedtls_x509_crt initialized through
@@ -394,6 +402,10 @@ int mbedtls_x509_crt_parse_der_with_ext_cb(mbedtls_x509_crt *chain,
  *                 temporary ownership of the CRT buffer until the CRT
  *                 is destroyed.
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param chain    The pointer to the start of the CRT chain to attach to.
  *                 When parsing the first CRT in a chain, this should point
  *                 to an instance of ::mbedtls_x509_crt initialized through
@@ -434,6 +446,10 @@ int mbedtls_x509_crt_parse_der_nocopy(mbedtls_x509_crt *chain,
  *                 long as the certificates are enclosed in the PEM specific
  *                 '-----{BEGIN/END} CERTIFICATE-----' delimiters.
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param chain    The chain to which to add the parsed certificates.
  * \param buf      The buffer holding the certificate data in PEM or DER format.
  *                 For certificates in PEM encoding, this may be a concatenation
@@ -458,6 +474,10 @@ int mbedtls_x509_crt_parse(mbedtls_x509_crt *chain, const unsigned char *buf, si
  *                 of failed certificates it encountered. If none complete
  *                 correctly, the first error is returned.
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param chain    points to the start of the chain
  * \param path     filename to read the certificates from
  *
diff --git a/include/mbedtls/x509_csr.h b/include/mbedtls/x509_csr.h
index fa7ef04a2..5975584da 100644
--- a/include/mbedtls/x509_csr.h
+++ b/include/mbedtls/x509_csr.h
@@ -82,6 +82,10 @@ mbedtls_x509write_csr;
  *
  * \note           CSR attributes (if any) are currently silently ignored.
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param csr      CSR context to fill
  * \param buf      buffer holding the CRL data
  * \param buflen   size of the buffer
@@ -96,6 +100,10 @@ int mbedtls_x509_csr_parse_der(mbedtls_x509_csr *csr,
  *
  * \note           See notes for \c mbedtls_x509_csr_parse_der()
  *
+ * \note           If #MBEDTLS_USE_PSA_CRYPTO is enabled, the PSA crypto
+ *                 subsystem must have been initialized by calling
+ *                 psa_crypto_init() before calling this function.
+ *
  * \param csr      CSR context to fill
  * \param buf      buffer holding the CRL data
  * \param buflen   size of the buffer